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Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation.

Molecular psychiatry - 1 Jun 2024

Liao Yundan, Yu Hao, Zhang Yuyanan, Lu Zhe, Sun Yaoyao, Guo Liangkun, Guo Jing, Kang Zhewei, Feng Xiaoyang, Sun Yutao, Wang Guishan, Su Zhonghua, Lu Tianlan, Yang Yongfeng, Li Wenqiang, Lv Luxian, Yan Hao, Zhang Dai, Yue Weihua

Abstract excerpt

Antipsychotic-induced weight gain (AIWG) is a common side effect of antipsychotic medication and may contribute to diabetes and coronary heart disease. To expand the unclear genetic mechanism underlying AIWG, we conducted a two-stage genome-wide association study in Han Chinese patients with schizophrenia. The study included a discovery cohort of 1936 patients and a validation cohort of 534 patients, with an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38336841
DOI: 10.1038/s41380-024-02447-2

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PEPD
PTPRD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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