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Article

Immunological comparison of pregnant Dahl salt-sensitive and Sprague-Dawley rats commonly used to model characteristics of preeclampsia.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Aug 2021

Taylor Erin B, George Eric M, Ryan Michael J, Garrett Michael R, Sasser Jennifer M

Abstract excerpt

The pregnant Dahl salt-sensitive (S) rat is an established preclinical model of superimposed spontaneous preeclampsia characterized by exacerbated hypertension, increased urinary protein excretion, and increased fetal demise. Because of the underlying immune system dysfunction present in preeclamptic pregnancies in humans, we hypothesized that the pregnant Dahl S rat would also have an altered immune status....

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Identifiers

PMID: 34105357
DOI: 10.1152/ajpregu.00298.2020
PMCID: PMC8409910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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