Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man.

doi:10.1007/BF01970146

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Article

Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man.

Pharmaceutisch weekblad. Scientific edition - 27 Apr 1990

Vree T B, Beneken Kolmer E W, Martea M, Bosch R, Hekster Y A, Shimoda M

Abstract excerpt

Sulfadimethoxine is metabolized by O-dealkylation, N4-acetylation and N1-glucuronidation. In man, only N1-glucuronidation and N4-acetylation takes place, leading to the final double conjugate N4-acetylsulfadimethoxine-N1-glucuronide. The N1-glucuronides are directly measured by high pressure liqu...

Topics

Acetylation
Adult
Chromatography, High Pressure Liquid
Dealkylation
Female
Glucuronates
Half-Life
Humans
Male
Middle Aged
Phenotype
Protein Binding
Sulfadimethoxine

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