Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man.

Pharmaceutisch weekblad. Scientific edition - 27 Apr 1990

Vree T B, Beneken Kolmer E W, Martea M, Bosch R, Hekster Y A, Shimoda M

Abstract excerpt

Sulfadimethoxine is metabolized by O-dealkylation, N4-acetylation and N1-glucuronidation. In man, only N1-glucuronidation and N4-acetylation takes place, leading to the final double conjugate N4-acetylsulfadimethoxine-N1-glucuronide. The N1-glucuronides are directly measured by high pressure liquid chromatography. When N4-acetylsulfadimethoxine is administered as parent drug, 30% of the dose is N1-glucuronidated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucuronates

Share to Half-Life

Share to Phenotype

Share to Protein Binding

Source

Identifiers

PMID: 2336339
DOI: 10.1007/BF01970146

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man.PMID 2336339Read ↗

Pharmacokinetics, N1-glucuronidation, and N4-acetylation of sulfa-6-monomethoxine in humans.Semantic proximity Read ↗

Pharmacokinetics and acetylation of sulfa-2-monomethoxine in humans.Semantic proximity Read ↗

Pharmacokinetics, acetylation-deacetylation, renal clearance, and protein binding of sulphamerazine, N4-acetylsulphamerazine, and N4-trideuteroacetylsulphamerazine in 'fast' and 'slow' acetylators.Semantic proximity Read ↗

Pharmacokinetics, metabolism and renal excretion of sulfatroxazole and its 5-hydroxy- and N4-acetyl-metabolites in man.Semantic proximity Read ↗

N-acetyltransferase (NAT) 1 and NAT2 enzyme activities drive interindividual variability in sulfamethoxazole N-acetylation.Semantic proximity Read ↗

N-acetylation phenotyping with sulphadimidine in a Turkish population.Semantic proximity Read ↗

N-acetylation of drugs. Pharmacogenetic studies in rabbits selected for their acetylator characteristics.Semantic proximity Read ↗

N-acetylation and oxidative capacity in aged volunteers determined with sulfamethazine and antipyrine.Semantic proximity Read ↗

N-acetylation of the heterocyclic amine batracylin by human liver.Semantic proximity Read ↗

Determination of the acetylator phenotype and pharmacokinetics of some sulphonamides in man.Semantic proximity Read ↗

Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man.Semantic proximity Read ↗

N-acetylation phenotyping with sulfamethazine in an Iranian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.