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DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage

18 May 2022

Abstract excerpt

Neural precursor cell-expressed developmentally down-regulated 8 (NEDD8), an ubiquitin-like protein, is an essential regulator of the DNA damage response. Numerous studies have shown that neddylation (conjugation of NEDD8 to target proteins) dysfunction causes several human diseases, such as cancer. Hence clarifying the regulatory mechanism of neddylation could provide insight into the mechanism of genome...

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PMID: 35582972
DOI: 10.1242/jcs.259514

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