Article
Immunohistochemical expression of IDH1 in gliomas: a tissue microarray-based approach.
Journal of cancer research and therapeutics - 1 Jan 2000
Sipayya Varuna, Sharma Ira, Sharma K C, Singh Avninder
Abstract excerpt
BACKGROUND: Mutations in the gene encoding isocitrate dehydrogenase (IDH1) have been reported in gliomas. This study analyses a series of 184 glioma cases in a tissue microarray (TMA)-based approach to assess the frequency of R132H point mutations in formalin-fixed, paraffin-embedded tissue samples. MATERIALS AND METHODS: A total of 195 gliomas (30 pilocytic astrocytoma (PA), 45 diffuse astrocytoma [DA], 75...
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