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Article

Molecular investigation of isocitrate dehydrogenase gene (IDH) mutations in gliomas: first report of IDH2 mutations in Indian patients.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Das Bibhu Ranjan, Tangri Rajiv, Ahmad Firoz, Roy Arnab, Patole Kamlakar

Abstract excerpt

Recent genome wide sequencing has identified mutations in IDH1/IDH2 predominantly in grade II-III gliomas and secondary glioblastomas which are associated with favorable clinical outcome. These mutations have become molecular markers of significant diagnostic and prognostic relevance in the assessment of human gliomas. In the current study we evaluated IDH1 (R132) and IDH2 (R172) in 32 gliomas of various grades...

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Source

Identifiers

PMID: 24460285
DOI: 10.7314/apjcp.2013.14.12.7261

Genes

IDH1
IDH2

Variants

Provenance

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