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Article

Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation

28 Jan 2013

Abstract excerpt

Lysine acetylation is an important posttranslational modification that regulates microtubules and microfilaments, but its effects on intermediate filament proteins (IFs) are unknown. We investigated the regulation of keratin 8 (K8), a type II simple epithelial IF, by lysine acetylation. K8 was basally acetylated and the highly conserved Lys-207 was a major acetylation site. K8 acetylation regulated filament...

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PMID: 23358244
DOI: 10.1083/jcb.201209028

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