Deacetylation via SIRT2 prevents keratin-mutation-associated injury and keratin aggregation.

Abstract excerpt

Keratin (K) and other intermediate filament (IF) protein mutations at conserved arginines disrupt keratin filaments into aggregates and cause human epidermolysis bullosa simplex (EBS; K14-R125C) or predispose to mouse liver injury (K18-R90C). The challenge for more than 70 IF-associated diseases is the lack of clinically utilized IF-targeted therapies. We used high-throughput drug screening to identify compounds...

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• Intermediate Filament Proteins
• Keratins
• Mice
• Mutation
• Sirtuin 2