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Article

Keratins turn over by ubiquitination in a phosphorylation-modulated fashion.

The Journal of cell biology - 1 May 2000

Ku N O, Omary M B

Abstract excerpt

Keratin polypeptides 8 and 18 (K8/18) are intermediate filament (IF) proteins that are expressed in glandular epithelia. Although the mechanism of keratin turnover is poorly understood, caspase-mediated degradation of type I keratins occurs during apoptosis and the proteasome pathway has been indirectly implicated in keratin turnover based on colocalization of keratin-ubiquitin antibody staining. Here we show...

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Identifiers

PMID: 10791969
DOI: 10.1083/jcb.149.3.547
PMCID: PMC2174842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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