Article
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.
Nature - 1 Jan 2021
Pastushenko Ievgenia, Mauri Federico, Song Yura, de Cock Florian, Meeusen Bob, Swedlund Benjamin, Impens Francis, Van Haver Delphi, Opitz Matthieu, Thery Manuel, Bareche Yacine, Lapouge Gaelle, Vermeersch Marjorie, Van Eycke Yves-Rémi, Balsat Cédric, Decaestecker Christine, Sokolow Youri, Hassid Sergio, Perez-Bustillo Alicia, Agreda-Moreno Beatriz, Rios-Buceta Luis, Jaen Pedro, Redondo Pedro, Sieira-Gil Ramon, Millan-Cayetano Jose F, Sanmatrtin Onofre, D'Haene Nicky, Moers Virginie, Rozzi Milena, Blondeau Jeremy, Lemaire Sophie, Scozzaro Samuel, Janssens Veerle, De Troya Magdalena, Dubois Christine, Pérez-Morga David, Salmon Isabelle, Sotiriou Christos, Helmbacher Francoise, Blanpain Cédric
Abstract excerpt
FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human cancers1-5. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. Here, using mouse models of skin squamous cell carcinoma and lung tumours, we found that deletion of Fat1 accelerates tumour initiation and malignant progression and promotes a...
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