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FAT1 somatic mutations in head and neck carcinoma are associated with tumor progression and survival.

Carcinogenesis - 13 Dec 2018

Lin Shu-Chun, Lin Li-Han, Yu Ssu-Yu, Kao Shou-Yen, Chang Kuo-Wei, Cheng Hui-Wen, Liu Chung-Ji

Abstract excerpt

In recent years, the incidence and mortality rates of head and neck squamous cell carcinoma (HNSCC) have increased worldwide. Therefore, understanding genomic alterations in HNSCC carcinogenesis is crucial for appropriate diagnosis and therapy. Protocadherin FAT1, which encodes 4588 amino acid residues, regulates complex mechanisms to promote oncogenesis or suppression of malignancies. Multiplex PCR-based...

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Source

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PMID: 30102337
DOI: 10.1093/carcin/bgy107

Genes

FAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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