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Article

Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation.

Cancer letters - 1 Dec 2016

Hayes Tyler F, Benaich Nathan, Goldie Stephen J, Sipilä Kalle, Ames-Draycott Ashley, Cai Wenjun, Yin Guangliang, Watt Fiona M

Abstract excerpt

Oral squamous cell carcinoma (OSCC) is genetically highly heterogeneous, which contributes to the challenges of treatment. To create an in vitro model that accurately reflects this heterogeneity, we generated a panel of HPV-negative OSCC cell lines. By whole exome sequencing of the lines and matched patient blood samples, we demonstrate that the mutational spectrum of the lines is representative of primary OSCC...

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Source

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Identifiers

PMID: 27693639
DOI: 10.1016/j.canlet.2016.09.014
PMCID: PMC5090049

Genes

FAT1
CASP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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