Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma.

doi:10.1038/s41416-024-02881-7

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Article

Recurrent somatic mutations of FAT family cadherins induce an aggressive phenotype and poor prognosis in anaplastic large cell lymphoma.

British journal of cancer - 1 Dec 2024

Villa Matteo, Sharma Geeta G, Malighetti Federica, Mauri Mario, Arosio Giulia, Cordani Nicoletta, Lobello Cosimo, Larose Hugo, Pirola Alessandra, D'Aliberti Deborah, Massimino Luca, Criscuolo Lucrezia, Pagani Lisa, Chinello Clizia, Mastini Cristina, Fontana Diletta, Bombelli Silvia, Meneveri Raffaella, Lovisa Federica, Mussolin Lara, Janikova Andrea, Pospíšilová Šárka, Turner Suzanne D, Inghirami Giorgio, Magni Fulvio, Urso Mario, Pagni Fabio, Ramazzotti Daniele, Piazza Rocco, Chiarle Roberto, Gambacorti-Passerini Carlo, Mologni Luca

Abstract excerpt

BACKGROUND: Anaplastic Large Cell Lymphoma (ALCL) is a rare and aggressive T-cell lymphoma, classified into ALK-positive and ALK-negative subtypes, based on the presence of chromosomal translocations involving the ALK gene. The current standard of treatment for ALCL is polychemotherapy, with a high overall survival rate. However, a subset of patients does not respond to or develops resistance to these therapies,...

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PMID: 39478125
DOI: 10.1038/s41416-024-02881-7
PMCID: PMC11589140

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