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Article

CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition.

Transplantation - 27 Mar 2013

Zheng Songmao, Tasnif Yasar, Hebert Mary F, Davis Connie L, Shitara Yoshihisa, Calamia Justina C, Lin Yvonne S, Shen Danny D, Thummel Kenneth E

Abstract excerpt

BACKGROUND: Higher concentrations of AM19 and AM1c9, secondary metabolites of cyclosporine A (CsA), have been associated with nephrotoxicity in organ transplant patients. The risk of renal toxicity may depend on the accumulation of CsA and its metabolites in the renal tissue. We evaluated the hyp...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23354298
DOI: 10.1097/TP.0b013e31827e6ad9
PMCID: PMC3604156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23354298-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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