Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro metabolism of cyclosporine A by human kidney CYP3A5.

Biochemical pharmacology - 1 Nov 2004

Dai Yang, Iwanaga Kazunori, Lin Yvonne S, Hebert Mary F, Davis Connie L, Huang Weili, Kharasch Evan D, Thummel Kenneth E

Abstract excerpt

The objectives of this study were to characterize and compare the metabolic profile of cyclosporine A (CsA) catalyzed by CYP3A4, CYP3A5 and human kidney and liver microsomes, and to evaluate the impact of the CYP3A5 polymorphism on product formation from parent drug and its primary metabolites. Three primary CsA metabolites (AM1, AM9 and AM4N) were produced by heterologously expressed CYP3A4. In contrast, only...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclosporine

Share to Cytochrome P-450 CYP3A

Share to Cytochrome P-450 Enzyme System

Share to Kidney

Share to Microsomes

Share to Testosterone

Source

Identifiers

PMID: 15450954
DOI: 10.1016/j.bcp.2004.07.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

In vitro metabolism of cyclosporine A by human kidney CYP3A5.PMID 15450954Read ↗

CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition.Semantic proximity Read ↗

Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro.Semantic proximity Read ↗

The concentration of cyclosporine metabolites is significantly lower in kidney transplant recipients with diabetes mellitus.Semantic proximity Read ↗

Influence of CYP3A5 genetic polymorphism on cyclosporine A metabolism and elimination in Chinese renal transplant recipients.Semantic proximity Read ↗

In vivo CYP3A activity is significantly lower in cyclosporine-treated as compared with tacrolimus-treated renal allograft recipients.Semantic proximity Read ↗

CYP3A5 genotype-phenotype analysis in the human kidney reveals a strong site-specific expression of CYP3A5 in the proximal tubule in carriers of the CYP3A5*1 allele.Semantic proximity Read ↗

Metabolism of sirolimus in the presence or absence of cyclosporine by genotyped human liver microsomes and recombinant cytochromes P450 3A4 and 3A5.Semantic proximity Read ↗

Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes.Semantic proximity Read ↗

Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.Semantic proximity Read ↗

Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.