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Article

Polymorphisms of multidrug resistance gene (MDR1) and cyclosporine absorption in de novo renal transplant patients.

Transplantation - 27 May 2007

Foote Clary J, Greer Wenda, Kiberd Bryce, Fraser Albert, Lawen Joseph, Nashan Bjorn, Belitsky Philip

Abstract excerpt

BACKGROUND: Several single nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) absorption in renal transplant patients. METHODS: An analysis of CsA absorption measured by the dose- and weight-adjusted 4 hr area under the time-concentration curve, AUC(0-4)/mg doseCsA/kg, was conducted on day 3 after transplantation, in 69...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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PMID: 17519790
DOI: 10.1097/01.tp.0000264197.88129.2e

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