Article
Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes.
Clinical pharmacology and therapeutics - 1 Dec 2004
Hesselink Dennis A, van Gelder Teun, van Schaik Ron H N, Balk Aggie H M M, van der Heiden Ilse P, van Dam Thea, van der Werf Marloes, Weimar Willem, Mathot Ron A A
Abstract excerpt
OBJECTIVE: Our objective was to determine the relationship between single nucleotide polymorphisms (SNPs) in the multidrug resistance 1 (MDR-1) gene and the cytochrome P450 (CYP) genes CYP3A4 and CYP3A5 and the pharmacokinetics of cyclosporine (INN, ciclosporin). METHODS: Cyclosporine pharmacokinetics of 151 kidney and heart transplant recipients undergoing maintenance therapy was described by use of nonlinear...
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