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Article

Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition.

Clinical pharmacology and therapeutics - 1 Dec 2012

Zheng S, Tasnif Y, Hebert M F, Davis C L, Shitara Y, Calamia J C, Lin Y S, Shen D D, Thummel K E

Abstract excerpt

We evaluated the hypothesis that cytochrome P450 3A5 (CYP3A5) expression can affect intrarenal tacrolimus accumulation. Tacrolimus was administered orally to 24 healthy volunteers who were selected on the basis of their CYP3A5 genotype. As compared with CYP3A5 nonexpressors, expressors had a 1.6-fold higher oral tacrolimus clearance and 2.0- to 2.7-fold higher metabolite/parent area under the curve (AUC) ratios...

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Identifiers

PMID: 23073208
DOI: 10.1038/clpt.2012.175
PMCID: PMC4038024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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