Article
Circumvention of daunorubicin resistance by a new tamoxifen derivative, toremifene, in multidrug-resistant cell line.
Japanese journal of cancer research : Gann - 1 Jun 1994
Urasaki Y, Ueda T, Nakamura T
Abstract excerpt
The reversing effect of toremifene, a new tamoxifen derivative, on multidrug resistance in a K562 subline and its mechanism were studied. K562 cells were cultured in serially increasing concentrations up to 1.0 microM daunorubicin (DNR), and were found to be 28 times more resistant to DNR in comp...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Carrier Proteins
- Chemical Phenomena
- Chemistry, Physical
- Daunorubicin
- Drug Resistance
- Drug Screening Assays, Antitumor
- Humans
- Leukemia, Myeloid
- Membrane Glycoproteins
- Phenotype
- Solubility
- Toremifene
- Tumor Cells, Cultured
- Verapamil