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Article

Reversal of multidrug resistance in HL-60 cells by verapamil and liposome-encapsulated doxorubicin.

Cancer letters - 1 May 1991

Sadasivan R, Morgan R, Fabian C, Stephens R

Abstract excerpt

The means of circumventing multidrug resistance was investigated in HL-60 and HL-60R (a drug resistance variant) cell lines. The HL-60R cell line was developed from the parent line by serial exposure to increasing concentrations of doxorubicin over a 4-month period. This drug resistant cell line expressed P-glycoprotein in its cell surface and is 80-fold more resistant than the parent cell line. Multidrug...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

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Source

Identifiers

PMID: 1673873
DOI: 10.1016/0304-3835(91)90211-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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