Article
Reversal of multidrug resistance in HL-60 cells by verapamil and liposome-encapsulated doxorubicin.
Cancer letters - 1 May 1991
Sadasivan R, Morgan R, Fabian C, Stephens R
Abstract excerpt
The means of circumventing multidrug resistance was investigated in HL-60 and HL-60R (a drug resistance variant) cell lines. The HL-60R cell line was developed from the parent line by serial exposure to increasing concentrations of doxorubicin over a 4-month period. This drug resistant cell line expressed P-glycoprotein in its cell surface and is 80-fold more resistant than the parent cell line. Multidrug...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Cell Membrane
- Cell Survival
- Dose-Response Relationship, Drug
- Doxorubicin
- Drug Resistance
- Drug Synergism
- Humans
- Liposomes
- Membrane Glycoproteins
- Phenotype