Article
Reversal of chemoresistance in malignant gliomas by calcium antagonists: correlation with the expression of multidrug-resistant p-glycoprotein.
Journal of neurosurgery - 1 Oct 1994
Kiwit J C, Hertel A, Matuschek A E
Abstract excerpt
Resistance to multiple drugs is often observed in malignant gliomas. The authors used a microtiter tetrazolium test to analyze primary in vitro chemoresistance and chemosensitivity of 15 early cultures of human malignant glioma exposed to 50 micrograms/ml (1,4-amino-2-methyl-5-pyrimidinyl)-methyl...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Combined Chemotherapy Protocols
- Cisplatin
- Drug Resistance
- Glioblastoma
- Humans
- Immunoenzyme Techniques
- Nimodipine
- Nimustine
- Phenotype
- Tumor Cells, Cultured
- Verapamil
- Vincristine