Article
The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro.
Cancer chemotherapy and pharmacology - 1 Jan 1997
Davey R A, Su G M, Hargrave R M, Harvie R M, Baguley B C, Davey M W
Abstract excerpt
The effectiveness of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) relative to that of amsacrine, idarubicin, daunorubicin and paclitaxel against three different forms of multidrug resistance (MDR) was determined using two sublines of the CCRF-CEM human leukaemia cell line, the P-glyco-...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Acridines
- Amsacrine
- Antineoplastic Agents
- Buthionine Sulfoximine
- Cell Line
- Cell Survival
- Daunorubicin
- Drug Resistance, Multiple
- HL-60 Cells
- Humans
- Idarubicin
- Leukemia
- Paclitaxel
- Phenotype
- RNA, Messenger
- Transcription, Genetic
- Tumor Cells, Cultured