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Article

A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.

Hypertension (Dallas, Tex. : 1979) - 1 Oct 2009

Luo Fang, Wang Yibo, Wang Xiaojian, Sun Kai, Zhou Xianliang, Hui Rutai

Abstract excerpt

NEDD4L is involved in the regulation of plasma volume and blood pressure by controlling cell surface expression of the kidney epithelial Na(+) channel. Previously, the cryptic splice variant rs4149601(G/A) A allele of NEDD4L, generating isoform I, was estimated to decrease blood pressure by downr...

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Identifiers

PMID: 19635985
DOI: 10.1161/HYPERTENSIONAHA.109.135103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19635985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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