A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients.

doi:10.1097/HJH.0b013e3283410390

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Article

A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients.

Journal of hypertension - 1 Feb 2011

Svensson-Färbom Patrik, Wahlstrand Björn, Almgren Peter, Dahlberg Jonas, Fava Cristiano, Kjeldsen Sverre, Hedner Thomas, Melander Olle

Abstract excerpt

OBJECTIVE: The capability of the protein NEDD4L to reduce renal tubular expression of epithelial Na+ channel (ENaC) is influenced by a functional rs4149601 G→A NEDD4L polymorphism. As diuretics and β-blockers inhibit renal sodium reabsorption and renin release, respectively, we hypothesized that the β-blocker or diuretic-induced blood pressure reduction and prevention of cardiovascular disease would be greater in...

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PMID: 21052022
DOI: 10.1097/HJH.0b013e3283410390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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