Article

Distinct gene-selective roles for a network of core promoter factors in <i>Drosophila</i> neural stem cell identity

2018-10-03

Abstract excerpt

The transcriptional mechanisms that allow neural stem cells (NSC) to balance self-renewal with differentiation are not well understood. Employing an in vivo RNAi screen we identify here NSC-TAFs, a subset of nine TATA-binding protein associated factors (TAFs), as NSC identity genes in Drosophila . We found that depletion of NSC-TAFs results in decreased NSC clone size, reduced proliferation, defective cell polari...

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Literature Corpus work: 08a6886b-9426-5332-981a-656341ae0bad
DOI: 10.1101/434597

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