Article
The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo.
Development (Cambridge, England) - 15 Apr 2017
Goolam Mubeen, Zernicka-Goetz Magdalena
Abstract excerpt
The separation of embryonic from extra-embryonic tissues within the inner cell mass to generate the epiblast (EPI), which will form the new organism, from the primitive endoderm (PE), which will form the yolk sac, is a crucial developmental decision. Here, we identify a chromatin modifier, Satb1, with a distinct role in this decision. Satb1 is differentially expressed within 16-cell-stage embryos, with higher...
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