Article
A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12.
BMC genomics - 26 Jan 2013
Fernandez-Rozadilla Ceres, Cazier Jean-Baptiste, Tomlinson Ian P, Carvajal-Carmona Luis G, Palles Claire, Lamas María J, Baiget Montserrat, López-Fernández Luis A, Brea-Fernández Alejandro, Abulí Anna, Bujanda Luis, Clofent Juan, Gonzalez Dolors, Xicola Rosa, Andreu Montserrat, Bessa Xavier, Jover Rodrigo, Llor Xavier, Moreno Víctor, Castells Antoni, Carracedo Ángel, Castellvi-Bel Sergi, Ruiz-Ponte Clara
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is a disease of complex aetiology, with much of the expected inherited risk being due to several common low risk variants. Genome-Wide Association Studies (GWAS) have identified 20 CRC risk variants. Nevertheless, these have only been able to explain part of the missing heritability. Moreover, these signals have only been inspected in populations of Northern European origin....
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