Article
Association of mitochondrial D-loop mutations with GSTM1 and GSTT1 polymorphisms in oral carcinoma: a case control study from northeast India.
Oral oncology - 1 Apr 2013
Mondal Rosy, Ghosh Sankar Kumar, Talukdar Fazlur Rahman, Laskar Ruhina Shirin
Abstract excerpt
OBJECTIVES: Mitochondrial dysfunction is a hallmark of cancer cells. Tobacco consumption in various forms is one of the major risk factors for the development of oral squamous cell carcinoma which makes the mitochondrial DNA susceptible to damage by reactive oxygen species. The GSTT1 and GSTM1 members of the glutathione S-transferase multigene family are candidate carcinogen metabolizing genes. Here we determined...
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