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Article

Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial.

Leukemia - 1 Jan 2016

Jenkinson S, Kirkwood A A, Goulden N, Vora A, Linch D C, Gale R E

Abstract excerpt

PTEN gene inactivation by mutation or deletion is common in pediatric T-cell acute lymphoblastic leukemia (T-ALL), but the impact on outcome is unclear, particularly in patients with NOTCH1/FBXW7 mutations. We screened samples from 145 patients treated on the MRC UKALL2003 trial for PTEN mutations using heteroduplex analysis and gene deletions using single nucleotide polymorphism arrays, and related genotype to...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26220040
DOI: 10.1038/leu.2015.206
PMCID: PMC4705426

Genes

PTEN
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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