Article
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Nature medicine - 1 Oct 2007
Palomero Teresa, Sulis Maria Luisa, Cortina Maria, Real Pedro J, Barnes Kelly, Ciofani Maria, Caparros Esther, Buteau Jean, Brown Kristy, Perkins Sherrie L, Bhagat Govind, Agarwal Archana M, Basso Giuseppe, Castillo Mireia, Nagase Satoru, Cordon-Cardo Carlos, Parsons Ramon, Zúñiga-Pflücker Juan Carlos, Dominguez Maria, Ferrando Adolfo A
Abstract excerpt
Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias and lymphomas (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors, which block a proteolytic cleavage required for NOTCH1 activation. However, the enthusiasm for these therapies has been tempered by tumor resistance and the paucity of information on the oncogenic programs regulated by...
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