Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.

doi:10.1136/jmedgenet-2012-101156

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.

Journal of medical genetics - 1 Apr 2013

Hwang Joo-Yeon, Lee Seung Hun, Go Min Jin, Kim Beom-Jun, Kou Ikuyo, Ikegawa Shiro, Guo Yan, Deng Hong-Wen, Raychaudhuri Soumya, Kim Young Jin, Oh Ji Hee, Kim Youngdoe, Moon Sanghoon, Kim Dong-Joon, Koo Heejo, Cha My-Jung, Lee Min Hye, Yun Ji Young, Yoo Hye-Sook, Kang Young-Ah, Cho Eun-Hee, Kim Sang-Wook, Oh Ki Won, Kang Moo Il, Son Ho Young, Kim Shin-Yoon, Kim Ghi Su, Han Bok-Ghee, Cho Yoon Shin, Cho Myeong-Chan, Lee Jong-Young, Koh Jung-Min

Abstract excerpt

BACKGROUND: Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population. METHODS: Association was tested using a logistic regression analysis. A meta-analysis was performed on the combined results using effect size and standard...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Gene Knockdown Techniques

Share to Osteogenesis

Share to Osteoporosis

Share to Osteoporotic Fractures

Share to Proto-Oncogenes

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 23349225
DOI: 10.1136/jmedgenet-2012-101156
PMCID: PMC4169276

Genes

MECOM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.PMID 23349225Read ↗

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.Semantic proximity Read ↗

Are bone mineral density loci associated with hip osteoporotic fractures? A validation study on previously reported genome-wide association loci in a Chinese population.Semantic proximity Read ↗

The role of genetic and epigenetic factors in determining the risk of spinal fragility fractures: new insights in the management of spinal osteoporosisSemantic proximity Read ↗

Metaanalysis Reveals Genetic Correlates of Osteoporosis PathogenesisSemantic proximity Read ↗

Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene.Semantic proximity Read ↗

Causal impact of DNA methylation on refracture in elderly individuals with osteoporosis – a prospective cohort studySemantic proximity Read ↗

Fine-Scale Haplotype Mapping Reveals an Association of the FTO Gene with Osteoporosis and Fracture Risk in Postmenopausal Women.Semantic proximity Read ↗

The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding.Semantic proximity Read ↗

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclastsSemantic proximity Read ↗

Genome‐wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritisSemantic proximity Read ↗

Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study.Semantic proximity Read ↗

Common and rare variants in the exons and regulatory regions of osteoporosis-related genes improve osteoporotic fracture risk prediction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.