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Article

Fine-Scale Haplotype Mapping Reveals an Association of the FTO Gene with Osteoporosis and Fracture Risk in Postmenopausal Women.

Genes - 1 Sept 2024

Greere Daniela, Haydar Sara, Grigorescu Florin, Manda Dana, Voicu Gabriela, Lautier Corinne, Poiana Catalina

Abstract excerpt

INTRODUCTION: The Fat Mass and Obesity-Associated (FTO) gene encodes a demethylase, which modulates RNA N6-methyladenosine (m6A) and plays a regulatory role in adipocyte differentiation and the pathogenesis of human obesity. METHODS: To understand the potential role of FTO in osteoporosis (OP), we investigated five single nucleotide variations (SNVs) in intron 1 (rs8057044, rs8050136, rs9939609, rs62033406, and...

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Bone Density
Share to Fractures, Bone
Share to Haplotypes
Share to Low Density Lipoprotein Receptor-Related Protein-5
Share to Osteoporosis, Postmenopausal
Share to Osteoporotic Fractures
Share to Postmenopause

Source

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Identifiers

PMID: 39336743
DOI: 10.3390/genes15091152
PMCID: PMC11431166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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