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Causal impact of DNA methylation on refracture in elderly individuals with osteoporosis – a prospective cohort study

3 Jun 2024

Abstract excerpt

BACKGROUND: Osteoporotic vertebral compression fractures (OVCF) in the elderly increase refracture risk post-surgery, leading to higher mortality rates. Genome-wide association studies (GWAS) have identified susceptibility genes for osteoporosis, but the phenotypic variance explained by these genes has been limited, indicating the need to explore additional causal factors. Epigenetic modifications, such as DNA...

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PMID: 38831438
DOI: 10.1186/s12891-024-07521-y

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