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Article

Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2013

Nicholson Chad K, Lambert Jonathan P, Molkentin Jeffery D, Sadoshima Junichi, Calvert John W

Abstract excerpt

OBJECTIVE: The aim of this study was to determine whether thioredoxin 1 (Trx1) mediates the cardioprotective effects of hydrogen sulfide (H2S) in a model of ischemic-induced heart failure (HF). APPROACH AND RESULTS: Mice with a cardiac-specific overexpression of a dominant negative mutant of Trx1 and wild-type littermates were subjected to ischemic-induced HF. Treatment with H2S as sodium sulfide (Na2S) not only...

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Identifiers

PMID: 23349187
DOI: 10.1161/ATVBAHA.112.300484
PMCID: PMC3827725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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