Article
Generation of RGS8 null mutant mice by Cre/loxP system.
The Kobe journal of medical sciences - 8 Feb 2008
Kuwata Hitoshi, Nakao Kazuki, Harada Takeshi, Matsuda Ikuo, Aiba Atsu
Abstract excerpt
Regulators of G-protein signaling (RGS) proteins are negative regulators of heterotrimeric guanine-nucleotide-binding proteins (G-proteins) by activating intrinsic GTPase activity of G alpha and thereby terminating G-protein coupled receptor-associated signal transduction. RGS8 belongs to B/R4 subfamily of RGS proteins and is expressed in the central nervous system, especially dense in cerebellar Purkinje cells....
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