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Article

Tumour-infiltrating CD4-, CD8- and FOXP3-positive immune cells as predictive markers of mortality in BRCA1- and BRCA2-associated breast cancer.

British journal of cancer - 1 Nov 2021

Jørgensen Nanna, Hviid Thomas Vauvert F, Nielsen Lise B, Sønderstrup Ida M H, Eriksen Jens Ole, Ejlertsen Bent, Gerdes Anne-Marie, Kruse Torben A, Thomassen Mads, Jensen Maj-Britt, Lænkholm Anne-Vibeke

Abstract excerpt

BACKGROUND: The prognostic value of tumour-infiltrating lymphocytes (TILs) in breast cancer is well-established. However, the investigation of specific T-cell subsets exclusively in BRCA-associated breast cancer is sparse. METHODS: Tumour tissues from 414 BRCA-mutated breast cancer patients were analysed by immunohistochemistry and digital image analysis for expression of CD4, CD8 and FOXP3 immune markers....

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Identifiers

PMID: 34365471
DOI: 10.1038/s41416-021-01514-7
PMCID: PMC8576013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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