Article
c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity.
Cell reports - 3 Jan 2017
Plaza-Sirvent Carlos, Schuster Marc, Neumann Yvonne, Heise Ulrike, Pils Marina C, Schulze-Osthoff Klaus, Schmitz Ingo
Abstract excerpt
Regulatory T (Treg) cells are critical for the shutdown of immune responses and have emerged as valuable targets of immunotherapies. Treg cells can rapidly proliferate; however, the homeostatic processes that limit excessive Treg cell numbers are poorly understood. Here, we show that, compared to conventional T cells, Treg cells have a high apoptosis rate ex vivo correlating with low c-FLIP expression....
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