Article
A weak Foxp3 hypomorph enhances spontaneous and therapeutic immune surveillance of cancer in mice
2019-03-07
Abstract excerpt
It is well established that therapeutic impairment of Foxp3 + regulatory T cells (Treg) in mice and humans favors immune rejection of solid tumors. Less explored are the genetic associations between Foxp3 allelic variants and tumor incidence, only sporadically reported in human studies. In this work, we tested and demonstrate that Foxp3 fGFP , an allele classified as hypomorphic in Th1 inflammatory contexts but...
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Identifiers and source
- Literature Corpus work
- b2895d6e-b158-5aed-bfd6-2957084607ca
- DOI
- 10.1101/570671