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Article

Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia.

Translational psychiatry - 22 Jan 2013

Urigüen L, Gil-Pisa I, Munarriz-Cuezva E, Berrocoso E, Pascau J, Soto-Montenegro M L, Gutiérrez-Adán A, Pintado B, Madrigal J L M, Castro E, Sánchez-Blázquez P, Ortega J E, Guerrero M J, Ferrer-Alcon M, García-Sevilla J A, Micó J A, Desco M, Leza J C, Pazos A, Garzón J, Meana J J

Abstract excerpt

Overexpression of the mammalian homolog of the unc-18 gene (munc18-1) has been described in the brain of subjects with schizophrenia. Munc18-1 protein is involved in membrane fusion processes, exocytosis and neurotransmitter release. A transgenic mouse strain that overexpresses the protein isofor...

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Identifiers

PMID: 23340504
DOI: 10.1038/tp.2012.149
PMCID: PMC3566728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23340504-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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