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Article

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse

15 Jan 2019

Abstract excerpt

Activity-dependent neuroprotective protein (ADNP), essential for brain formation, was discovered as a leading de novo mutated gene causing the autism-like ADNP syndrome. This syndrome is phenotypically characterized by global developmental delays, intellectual disabilities, speech impediments, and motor dysfunctions. The Adnp haploinsufficient mouse mimics the human ADNP syndrome in terms of synapse density and...

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PMID: 30664622
DOI: 10.1038/s41398-018-0357-6

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