Article
Identification of a synthetic muramyl peptide derivative with enhanced Nod2 stimulatory capacity.
Innate immunity - 1 Oct 2013
Rubino Stephen J, Magalhaes Joao G, Philpott Dana, Bahr George M, Blanot Didier, Girardin Stephen E
Abstract excerpt
Muramyl peptides (MPs) represent the building blocks of bacterial peptidoglycan, a critical component of bacterial cell walls. MPs are well characterized for their immunomodulatory properties, and numerous studies have delineated the role of MPs or synthetic MP analogs in host defense, adjuvanticity and inflammation. More recently, Nod1 and Nod2 have been identified as the host sensors for specific MPs, and, in...
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