Article
Enhancement of Muramyl Dipeptide-Dependent NOD2 Activity by a Self-Derived Peptide.
Journal of cellular biochemistry - 1 May 2017
Mann Jasdeep K, Shen Jiaochen, Park Sheldon
Abstract excerpt
Nucleotide-binding and oligomerization domain like receptors (NLR) are pattern recognition receptors used to provide rapid immune response by detecting intracellular pathogen-associated molecules. Loss of NLR activity is implicated in genetic disorders, disruption of adaptive immunity, and chronic inflammation. One NLR protein, NOD2, is frequently mutated in Crohn's disease (CD), which is an inflammatory disease...
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