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Article

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

18 Aug 2014

Abstract excerpt

Innate immunity confers an immediate nonspecific mechanism of microbial recognition through germ line-encoded pattern recognition receptors (PRRs). Of these, Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) have shaped our current understanding of innate regulation of adaptive immunity. It is now recognized that PRRs are paramount in instructing an...

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PMID: 25136133
DOI: 10.1073/pnas.1400478111

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