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Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae

14 Jun 2016

Abstract excerpt

The innate immune system recognizes microbial pathogens via pattern recognition receptors. One such receptor, NOD2, via recognition of muramyl dipeptide (MDP), triggers a distinct network of innate immune responses, including the production of interleukin-32 (IL-32), which leads to the differentiation of monocytes into dendritic cells (DC). NOD2 has been implicated in the pathogenesis of human leprosy, yet it is...

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PMID: 27297389
DOI: 10.1128/iai.00334-16

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