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Article

Hepatitis C virus envelope glycoprotein signatures are associated with treatment failure and modulation of viral entry and neutralization.

The Journal of infectious diseases - 15 Apr 2013

Schvoerer Evelyne, Moenne-Loccoz Rémy, Murray John M, Velay Aurélie, Turek Marine, Fofana Isabel, Fafi-Kremer Samira, Erba Anne-Claire, Habersetzer François, Doffoël Michel, Gut Jean-Pierre, Donlin Maureen J, Tavis John E, Zeisel Mirjam B, Stoll-Keller Françoise, Baumert Thomas F

Abstract excerpt

BACKGROUND: A major challenge for antiviral treatment of hepatitis C virus (HCV) infection is viral resistance, potentially resulting from the high variability of HCV envelope glycoproteins and subsequent selection of strains with enhanced infectivity and/or immune escape. METHODS: We used a bioinformatics and functional approach to investigate whether E1/E2 envelope glycoprotein structure and function were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23335805
DOI: 10.1093/infdis/jit032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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