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Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistance

14 Dec 2014

Abstract excerpt

For hepatitis C virus (HCV) and other highly variable viruses, broadly neutralizing mAbs are an important guide for vaccine development. The development of resistance to anti-HCV mAbs is poorly understood, in part due to a lack of neutralization testing against diverse, representative panels of HCV variants. Here, we developed a neutralization panel expressing diverse, naturally occurring HCV envelopes (E1E2s)...

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PMID: 25500884
DOI: 10.1172/jci78794

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