Article
Genotype 1 hepatitis C virus envelope features that determine antiviral response assessed through optimal covariance networks.
PloS one - 1 Jan 2013
Murray John M, Moenne-Loccoz Rémy, Velay Aurélie, Habersetzer François, Doffoël Michel, Gut Jean-Pierre, Fofana Isabel, Zeisel Mirjam B, Stoll-Keller Françoise, Baumert Thomas F, Schvoerer Evelyne
Abstract excerpt
The poor response to the combined antiviral therapy of pegylated alfa-interferon and ribavarin for hepatitis C virus (HCV) infection may be linked to mutations in the viral envelope gene E1E2 (env), which can result in escape from the immune response and higher efficacy of viral entry. Mutations that result in failure of therapy most likely require compensatory mutations to achieve sufficient change in envelope...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.