Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperhomocysteinemic mice show cognitive impairment without features of Alzheimer's disease phenotype.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Rhodehouse Bryce C, Erickson Michelle A, Banks William A, Bearden Shawn E

Abstract excerpt

Hyperhomocysteinemia (HHcy) is associated with cognitive impairment and Alzheimer's disease. Whether this association is mechanistic remains unclear. Here, we used a mouse model to test the hypothesis that HHcy increases levels of amyloid-β (Aβ) transporters in microvessels that form the blood-brain barrier, elevates Aβ content (Aβ40 and Aβ42) in the brain, and impairs cognitive performance. Mice with HHcy and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Cognition Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperhomocysteinemia

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Mice, Transgenic

Share to Phenotype

Source

Identifiers

PMID: 23334704
DOI: 10.3233/JAD-122347

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperhomocysteinemic mice show cognitive impairment without features of Alzheimer's disease phenotype.PMID 23334704Read ↗

Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling.Semantic proximity Read ↗

Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.Semantic proximity Read ↗

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.Semantic proximity Read ↗

Cerebrovascular phenotypes in mouse models of Alzheimer's disease.Semantic proximity Read ↗

Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels.Semantic proximity Read ↗

Retinal vascular dysfunction in the <i> Mthfr <sup>677C>T</sup> </i> mouse model of cerebrovascular diseaseSemantic proximity Read ↗

Animal models of cerebral amyloid angiopathy.Semantic proximity Read ↗

The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular networkSemantic proximity Read ↗

Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Endothelial expression of human APP leads to cerebral amyloid angiopathy in miceSemantic proximity Read ↗

The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.