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Article

Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women.

Cancer research - 15 Mar 2013

Lee Eunjung, Van Den Berg David, Hsu Chris, Ursin Giske, Koh Woon-Puay, Yuan Jian-Min, Stram Daniel O, Yu Mimi C, Wu Anna H

Abstract excerpt

TGF-β plays a critical role in normal mammary development and morphogenesis. Decreased TGF-β signaling has been associated with increased mammographic density. Percent mammographic density (PMD) adjusted for age and body mass index (BMI) is a strong risk factor and predictor of breast cancer risk. PMD is highly heritable, but few genetic determinants have been identified. We investigated the association between...

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Identifiers

PMID: 23333936
DOI: 10.1158/0008-5472.CAN-12-1870
PMCID: PMC3740538

Genes

TGFB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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