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Hormone metabolism genes and mammographic density in Singapore Chinese women.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2013

Lee Eunjung, Su Yu-Chen, Lewinger Juan Pablo, Hsu Chris, Van Den Berg David, Ursin Giske, Koh Woon-Puay, Yuan Jian-Min, Stram Daniel O, Yu Mimi C, Wu Anna H

Abstract excerpt

BACKGROUND: Female steroid hormone levels and exogenous hormone use influence breast cancer risk. We investigated the association between genetic variation in the hormone metabolism and signaling pathway and mammographic density, a strong predictor of breast cancer risk. METHODS: We genotyped 161 SNPs in 15 hormone metabolism pathway gene regions and evaluated mammographic density in 2,038 Singapore Chinese...

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PMID: 23429186
DOI: 10.1158/1055-9965.EPI-13-0157
PMCID: PMC4197055

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